Matrix metalloproteinases in gastrointestinal cancer
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چکیده
منابع مشابه
Matrix metalloproteinases in cancer.
The extracellular matrix (ECM) holds cells together and maintains the three-dimensional structure of the body. It also plays critical roles in cell growth, differentiation, survival and motility. For a tumour cell to metastasize from the primary tumour to other organs, it must locally degrade ECM components that are the physical barriers for cell migration. The key enzymes responsible for ECM b...
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results based on the recent researches, certain mmps play critical role in breast cancer initiation, invasion, and metastasis. they can be regarded as predictive biomarkers of primary diagnosis and prognosis of breast cancer and have predictive value for evaluation of disease, tumor recurrence, invading of tumor cells to other sites and therapeutic outcomes. conclusions in summary, the results ...
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Matrix metalloproteinases (MMPs) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. MMPs have been demonstrated to increase the permeability of the blood–brain barrier (BBB) by degrading the c...
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Matrix metalloproteinases (MMPs) comprise a family of 23 zinc-dependent human endopeptidases that can degrade virtually all components of the extracellular matrix (ECM). They are classified into eight subgroups according to their structure and into six subgroups based on their substrate-specificity. MMPs have been implicated in inflammation, tissue destruction, cell migration, arthritis, vascul...
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ژورنال
عنوان ژورنال: Gut
سال: 1998
ISSN: 0017-5749,1468-3288
DOI: 10.1136/gut.43.2.161